From my bitter experience with Graphics Cards, my Machine and KRS. I have learned several things. If the Graphics Card is one of the 8000 series this in theory should out perform my lowly 7600gs. I have always been puzzled with Overmarze mentioning poor performance from his GPU. I don't know what CPU he has.
My 7600gs performs pretty well now even on the latest Power thingy Class 66 Scenario on the Paddington line with everything on high and switched on apart from detailed shadows. No Judders.
The things that most effects my KRS performance is how defragmented the drive with Railsim on is. In this case my D Drive. If I have worked on my Route 0.2% defragmentation is enough to drop my framerates by 10fps and produce Judder. My main Drive C also needs regular defrags to keep KRS running smoothly. The built in XP defragmentor doesn't do a good enough job and sometimes can make things worse. Perfect Disk 2008 free for 30 days
http://www.raxco.com/ is the best one I have tried. I liked it so much I bought the company

the program really. ( for those of us old enough to remember the Victor Kyam.)
If you have HP Imaging Software a stealthy part of this interferes with the way the program loads and results in erratic performance. I don't know how it does this but there could be other processes on peoples machines which do something similar.
Windows Defender knocks framerates by 12 or more fps if it is switched on and monitoring. Other background processes seem to have less effect and it is worth trying out a variety of setups here depending on what your PC needs to run to keep it stable.
The GPU settings, Drivers and the Multisampling set in the game in the start option play a major part.
Multisampling set to zero on my machine makes the game unplayable. 3 seems to be the best setting for me. This will vary on other machines and it is worth experimenting with.
Page Files are next mine runs best with a fixed sized large file on Drive D and letting the OS control the PF on Drive C which holds XP.
Finally a build up of Dust inside the machine can cause problems. A can of Compressed Air is needed here. No Hoovering.
For full information there are a variety of topics on here related to my problems which have an abundance of good advice and solutions. What I am saying is that any of the Graphics Cards Tested by Kuju with KRS should be able to run the program well and a decent 7000 series and upwards Card should not be immeadiately blamed for poor performance. My old machine with an FX5200 ran KRS better than my Latest Machine until I had gone through weeks of messing about as described above.
Regards James.