From the RailWorks launcher, click on Tools & Docs tab, then click on the "Clear Cache" button.
If that doesn't fix the problem, you may need to update your PhysX, or try installing the ones that comes with RailWorks.
Navigate to where you have RailWorks installed and find the Install folder; example c:\steam\steamapps\common\railworks\install
Find and run the "PhysX_6.10.25_SystemSoftware.exe" file to install the version of PhysX drivers that comes with RailWorks.
RailWorks Route & Scenario addons, video tutorials and other resources at http://www.RRYard.com